Gold-Standard Human Science
Too often, we see supplement brands claim their products are “supported by hundreds or thousands of studies”—even when those studies are based mainly on early laboratory or animal research that may not translate well to everyday human use.
That’s why, for EVYLO, we focus on the types of evidence that matter the most to people: gold-standard human research. This includes:
- Randomized controlled trials (RCTs) on humans
- Meta-analyses of human RCTs¹
- These study designs are widely considered the most reliable forms of clinical research because they are designed to minimize bias and provide dependable insights into how ingredients may work in people.²
- Even when focusing strictly on these gold-standard study types, the key ingredients in EVYLO have been evaluated across hundreds of human RCTs.
- When a strong meta-analysis already exists, we prioritize sharing that summary rather than individual studies.
- It may be less flashy—but it’s cleaner, clearer, and far less overwhelming. 😉
- Below are the key examples of gold-standard human research supporting EVYLO ingredients.³
¹A meta-analysis is only meaningful when paired with a systematic review, which helps reduce bias by evaluating the entire body of evidence—not just select studies.
²Duke Medical Center Library & Archives. Study Design: Introduction to Evidence-Based Practice. Updated September 17, 2025. Accessed November 3, 2025. https://guides.mclibrary.duke.edu/ebm/studydesign
³Additional data are on file.
EVYLO’s Ingredients Support Healthy Cholesterol & Triglyceride (TG) Levels*
Year: 2011
Study Design: Human randomized controlled trial
Number of Participants: 237
Conclusion: At the right daily serving, EVYLO's ingredients may support healthy levels of total cholesterol, LDL-C (“bad cholesterol”), HDL-C (“good cholesterol”), and TG.
Read MoreYear: 2013
Study Design: Human randomized controlled trial
Number of Participants: 24
Conclusion: At the right daily serving, EVYLO’s ingredients may support healthy levels of total cholesterol, LDL-c (“bad cholesterol”), HDL-c (“good cholesterol”), and TG
Read MoreYear: 2013
Study Design: Human randomized controlled trial
Number of Participants: 77
Conclusion: At the right daily serving, EVYLO’s ingredients may support healthy levels of total cholesterol, LDL-c (“bad cholesterol”), HDL-c (“good cholesterol”), and TG
Read MoreYear: 2013
Study Design: Human randomized controlled trial
Number of Participants: 144
Conclusion: At the right daily serving, EVYLO's ingredients may support healthy levels of total cholesterol, LDL-C (“bad cholesterol”), HDL-C (“good cholesterol”), and TG.
Read MoreYear: 2019
Study Design: Human Randomized Controlled Trial
Number of Participants: 60
Conclusion: At the Right Daily Serving, EVYLO’s Ingredients May Support Healthy Levels of Total Cholesterol, LDL-C (“Bad Cholesterol”), HDL-C (“Good Cholesterol”), and TG
Read MoreYear: 2021
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs Included: 46
Number of Participants: 4,158
Conclusion: At the right daily serving, EVYLO's ingredients may support healthy levels of total cholesterol, LDL-C (“bad cholesterol”), HDL-C (“good cholesterol”), and TG.
Read MoreYear: 2022
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs: 14
Number of Participants: 258
Conclusion: At the right daily serving, certain supplement ingredients of EVYLO provide better support than others with respect to maintaining healthy levels of LDL-C (“bad cholesterol”) and TG.
Read MoreYear: 2022
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs: 131
Number of Participants: 13,062
Conclusion: At the right daily serving, certain supplement ingredients of EVYLO provide better support than others with respect to maintaining healthy levels of LDL-C (“bad cholesterol”) and TG.
Read MoreYear: 2023
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs Included: 18
Number of Participants: 1,788
Conclusion: At the right daily serving, EVYLO's ingredients may support healthy levels of total cholesterol, LDL-C (“bad cholesterol”), HDL-C (“good cholesterol”), and TG.
Read MoreYear: 2023
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs Included: 44
Number of Participants: 4,606
Conclusion: At the right daily serving, EVYLO's ingredients may support healthy levels of total cholesterol, LDL-C (“bad cholesterol”), HDL-C (“good cholesterol”), and TG.
Read MoreEVYLO’s Ingredients Support Healthy Blood Pressure*
Year: 2015
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs Included: 27
Number of Participants: 2,569
Conclusion: At the right daily serving, EVYLO's ingredients may support healthy blood pressure.
Read MoreYear: 2017
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs Included: 11
Number of Participants: 65,790
Conclusion: At the right daily serving, EVYLO's ingredients may support healthy blood pressure.
Read MoreYear: 2022
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs: 26
Number of Participants: 1831
Conclusion: At the right daily serving, EVYLO's ingredients may support healthy blood pressure.
Read MoreEVYLO’s Ingredients Support Healthy Blood Sugar Metabolism*
Year: 2015
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs Included: 27
Number of Participants: 2,569
Conclusion: At the right daily serving, EVYLO's ingredients may support healthy blood sugar metabolism.
Read MoreYear: 2021
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs Included: 46
Number of Participants: 4,158
Conclusion: At the right daily serving, EVYLO's ingredients may support healthy blood sugar metabolism.
Read MoreEVYLO’s Ingredients Support Healthy Blood Circulation*
Year: 2012
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs Included: 15
Number of Participants: 55,764
Conclusion: At the right daily serving, EVYLO's ingredients may support healthy blood circulation.
Read MoreYear: 2016
Study design: systematic review and meta-analysis of human RCTs
Number of RCTs included: 30
Number of participants: 82,334
Conclusion: At the right daily serving, EVYLO’s ingredients may support healthy blood circulation.
Read MoreYear: 2017
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs Included: 22
Number of Participants: 82,723
Conclusion: At the right daily serving, EVYLO's ingredients may support healthy blood circulation.
Read MoreYear: 2017
Study Design: systematic review and meta-analysis of human RCTs
Number of RCTs Included: 11
Number of Participants: 65,790
Conclusion: At the right daily serving, EVYLO’s ingredients may support healthy blood circulation.
Read MoreYear: 2019
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs Included: 12
Number of Participants: 47,523
Conclusion: At the right daily serving, EVYLO’s ingredients may support healthy blood circulation.
Read MoreYear: 2021
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs Included: 35
Number of Participants: 24,525
Conclusion: At the right daily serving, EVYLO’s ingredients may support healthy blood circulation.
Read MoreYear: 2022
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs Included: 884
Number of Participants: 883,627
Conclusion: At the right daily serving, EVYLO’s ingredients may support healthy blood circulation.
Read MoreYear: 2024
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs Included: 21
Number of Participants: 115,559
Conclusion: At the right daily serving, EVYLO’s ingredients may support healthy blood circulation.
Read MoreEVYLO’s Ingredients Support Overall Mental and Physical Well-Being*
Year: 2019
Study Design: Human randomized controlled trial
Number of Participants: 180
Conclusion: At the right daily serving, EVYLO’s ingredients may help support cognitive function and mental clarity.
Read MoreYear: 2021
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs: 6
Number of Participants: 584
Conclusion: At the right daily serving, EVYLO’s ingredients may help support a healthy mood and emotional well-being.
Read MoreYear: 2022
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs Included: 13
Number of Participants: 1,126
Conclusion: At the right daily serving, EVYLO’s ingredients may support the body’s natural energy production.
Read MoreYear: 2024
Study Design: Systematic review and meta-analysis of human RCTs
Number of RCTs: 28
Number of Participants: 830
Conclusion: At the right daily serving, EVYLO’s ingredients may help protect muscles from stress and support recovery.
Read More